منابع مشابه
ASK-753, a new iron-containing antibiotic.
A new iron-containing peptide which inhibits the growth of Gram-positive and some Gram-negative bacteria was isolated from the broth of Streptomyces AS-K-753. The antibiotic was obtained as light buff plates. On acid hydrolysis eight amino acids, three organic acids and one keto acid could be detected. ASK-753 is similar in many properties to the sideromycin but differs from it in certain cruci...
متن کاملA9145, a new adenine-containing antifungal antibiotic. II. Biological activity.
A9145 activity was detected in mouse blood. Administration of 10 mg/kg for 3 days extended the survival time of mice infected with C. albicans 128 % ; equivalent doses of amphotericin B extended survival time \\2%. A total dose of 31.25mg/kg administered over a 5-day period reduced by 400-fold the number of Candida recovered from kidney homogenates of infected mice. A combination of amphoterici...
متن کاملStructure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis.
A family of dinuclear iron cluster-containing oxygenases that catalyze β-hydroxylation tailoring reactions in natural product biosynthesis by nonribosomal peptide synthetase (NRPS) systems was recently described [Makris, T. M., Chakrabarti, M., Münck, E., and Lipscomb, J. D. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 15391-15396]. Here, the 2.17 Å X-ray crystal structure of the archetypal enzyme...
متن کاملDmd050294 744..753
A physiologically based pharmacokinetic (PBPK) modeling approach was used to assess the prediction accuracy of propofol hepatic and extrahepatic metabolic clearance and to address previously reported underprediction of in vivo clearance based on static in vitro–in vivo extrapolation methods. The predictive capacity of propofol intrinsic clearance data (CLint) obtained in human hepatocytes and l...
متن کاملDmm017624 743..753
Hepatocellular carcinoma (HCC) is a deadly disease, often unnoticed until the late stages, when treatment options become limited. Thus, there is a crucial need to identify biomarkers for early detection of developing HCC, as well as molecular pathways that would be amenable to therapeutic intervention. Although analysis of human HCC tissues and serum components may serve these purposes, inabili...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1969
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.22.106